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Our 24/7 cancer helpline provides information and answers for people dealing with cancer. We can connect you with trained cancer information specialists who will answer questions about a cancer diagnosis and provide guidance and a compassionate ear.
Live Chat available weekdays, 7:00 am - 6:30 pm CT
Call us at 1-800-227-2345
Available any time of day or night
Our highly trained specialists are available 24/7 via phone and on weekdays can assist through online chat. We connect patients, caregivers, and family members with essential services and resources at every step of their cancer journey. Ask us how you can get involved and support the fight against cancer. Some of the topics we can assist with include:
For medical questions, we encourage you to review our information with your doctor.
For some people with cancer of unknown primary (CUP), treatment can remove or destroy the cancer. The end of treatment can be both stressful and exciting. You may be relieved to finish treatment, but it’s hard not to worry about cancer coming back. This is very common if you have had cancer.
For other people, the cancer might never go away completely. Some people may get regular treatment with chemotherapy or targeted therapy or other treatments to try and help control the cancer and its side effects. Learning to live with cancer that does not go away can be difficult and very stressful.
Life after CUP means returning to some familiar things and making some new choices.
After you have completed treatment, your doctors will still want to watch you closely. It is very important that you go to all of your follow-up appointments. During these visits, your doctors will ask questions about any problems you are having and may examine you and order lab or imaging tests to look for signs of cancer or treatment side effects. Almost any cancer treatment can have side effects. Some last for a few weeks to months, but others can last the rest of your life. This is the time to talk to your cancer care team about any changes or problems you notice and any questions or concerns you have.
Most doctors recommend careful follow-up, with a physical exam and review of symptoms, every 3 to 6 months for the first few years. After that, you should have a follow-up appointment at least every year. Lab tests might also be done. Scans are not usually needed at each visit, but should be done if there are any suspicious symptoms or physical findings.
If you have had surgery, your health care team may suggest that you meet with a nutritionist, who can help you if you need to adjust to changes in your eating habits.
Talk with your doctor about developing a survivorship care plan for you.This plan might include:
Eating right can be hard for anyone, and it may have gotten tougher during cancer treatment. If you have lost or are losing weight or if you are having trouble eating, do the best you can. Eat what appeals to you. Eat what you can, when you can. You might find it helps to eat small portions every 2 to 3 hours until you feel better. Now is not the time to restrict your diet. Try to keep in mind that these problems usually improve over time. Your cancer team may refer you to a dietitian, a nutrition expert who can give you ideas on how to fight some of the side effects of your treatment.
Even after treatment, it’s very important to keep your health insurance. Tests and doctor visits cost a lot, and even though no one wants to think of their cancer coming back, this could happen.
At some point after your cancer treatment, you might find yourself seeing a new doctor who doesn’t know your medical history. It’s important to keep copies of your medical records to give your new doctor the details of your diagnosis and treatment. Learn more in Keeping Copies of Important Medical Records.
If you have or have had CUP, you probably want to know if there are things you can do that might lower your risk of the cancer growing or coming back, such as exercising, eating a certain type of diet, or taking nutritional supplements. Unfortunately, it’s not yet clear if there are things you can do that will help. However, we do know that certain changes can have positive effects on your health that can go beyond your risk of cancer.
Tobacco use has been linked to some cancers, so not smoking might help reduce your risk. We don’t know for certain if this will help, but we do know that it can help improve your appetite and overall health. It can also reduce the chance of developing other types of cancer. If you want to quit smoking and need help, call the P站视频 at 1-800-227-2345. You can also learn more in How to Quit Smoking.
To help maintain good health, survivors should also :
So far, dietary supplements (including vitamins, minerals, and herbal products) have not been shown to clearly help lower the risk of cancer progressing or coming back. This doesn’t mean that no supplements will help, but it’s important to know that none have been proven to do so.
Dietary supplements are not regulated like medicines in the United States. They do not have to be proven effective (or even safe) before being sold, although there are limits on what they are allowed to claim they can do. If you’re thinking about taking any nutritional supplement, talk to your health care team first. They can help you decide which ones you can use safely while avoiding those that might be harmful.
If the cancer does come back at some point, your treatment options will depend on where the cancer is located, what treatments you’ve had before, and your health and personal preferences.
For more general information on recurrence, see Understanding Recurrence.
People who’ve had a CUP can still get other cancers. Since the location where a cancer of unknown primary (CUP) started is not known, survivors of CUP can get any type of second cancer; in fact, CUP survivors are at higher risk for getting some other types of cancer. Also, certain types of cancer and cancer treatments can be linked to a higher risk of second cancers.
See Second Cancers in Adults for more information about causes of second cancers.
Feeling depressed, anxious, or worried is normal when cancer is a part of your life. Some people are affected more than others. But everyone can benefit from help and support from friends and family, religious groups, support groups, professional counselors, or others. Learn more in Life After Cancer.
Developed by the P站视频 medical and editorial content team with medical review and contribution by the American Society of Clinical Oncology (ASCO).
Kushi LH, Doyle C, McCullough M, Rock CL, Demark-Wahnefried W, Bandera EV, Gapstur S, Patel AV, Andrews K, Gansler T; P站视频 2010 Nutrition and Physical Activity Guidelines Advisory Committee. P站视频 Guidelines on nutrition and physical activity for cancer prevention: Reducing the risk of cancer with healthy food choices and physical activity. CA Cancer J Clin. 2012 Jan-Feb;62(1):30-67.
Rock CL, Thomson C, Gansler T, et al. P站视频 guideline for diet and physical activity for cancer prevention. CA: A Cancer Journal for Clinicians. 2020;70(4). doi:10.3322/caac.21591. Accessed at https://onlinelibrary.wiley.com/doi/full/10.3322/caac.21591 on June 9, 2020.
Last Revised: May 27, 2025
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