Research We Fund: Extramural Discovery Science (EDS)

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Cancer Detection and Experimental Therapeutics (PF-CDET)

Areas Reviewed

  • Biomarker identification and pre-clinical development, including liquid biopsy and molecular imaging

  • Pre-clinical modeling to identify factors (such as microbiota, pathogens, nutrition, metabolism, oxygen levels, oncogenes, and tumor suppressor genes) and their mechanisms of action contributing to cancer progression

  • Mechanisms of therapeutic response, including tumor evolution and treatment resistance

  • Mechanisms of treatment-associated morbidities

  • Active and passive immune therapies for cancer, adoptive transfer of autologous or allogeneic hematopoietic cells, and targeted delivery of toxic payloads

  • Isolation, testing, and synthesis of natural products

  • Modification and development of drugs

  • Toxicity and effectiveness of therapeutic agents and drug delivery systems (including nanotechnology and microbial strategies)

  • Molecular imaging for pre-clinical therapeutic development

  • Pharmacology/pharmacogenetics/pharmacogenomics

  • Gene therapies and gene target validation