Research We Fund: Extramural Discovery Science (EDS)

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Cell Biology and Immunology (PF-CBI)

Areas Reviewed

  • Cellular events, mechanisms, structural components, and signaling involved in mitosis and cell fate in vertebrates, invertebrates, and yeast

  • Organelle biology involving the nucleus, the cytoskeleton, and membrane-bound organelles, including the trafficking of organelles and their constituents

  • Biology of developing systems (e.g., cell differentiation, morphogenesis, and genetics) and its relationship to cancer

  • Cell-cell interactions, adhesion, cell polarity, and the signaling events responsible for the pre-invasive to invasive transition and metastatic spread

  • Cellular and molecular events mediating tumor-stroma interactions, tumor-induced alterations of the extracellular matrix, tumor cell dormancy, tumor angiogenesis and lymphangiogenesis, and the specific niche environment in tumorigenesis

  • Stromal components and their mechanism of interactions within a tumor microenvironment

  • Immune tolerance and hematopoiesis

  • Molecular, structural, biochemical, and biophysical aspects of the immune system including cell types, cytokines, antigen processing, antibody molecules, and deficiencies